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Sildenafil is an effective treatment for erectile dysfunction in men with diabetes,114 patients on dialysis and after renal transplantation,115 multiple sclerosis,81 Parkinson disease,116 spinal cord injury,117 spina bifida,118 and familial amyloidotic polyneuropathy.119

From: Aminoff's Neurology and General Medicine (Fifth Edition), 2014

Related terms:

Adnan A. Badwan, ... Mahmoud Ashour, in Analytical Profiles of Drug Substances and Excipients , 2001


Titrimetric Analysis

Sildenafil citrate (250 mg) is dissolved in 50mL of glacial acetic acid, titrated with 0.1M perchloric acid, with the end point being detected potentiometrically. Each milliliter of 0.1M perchloric acid VS is equivalent to 66.67 mg of Sildenafil citrate, calculated as C HNOS • CHO . This method is suitable to assay Sildenafil citrate in its bulk drug form, and in formulated products [3] .

In this method, 160 mg of Sildenafil citrate was accurately weighed and dissolved in 50 mL of a 20:80 mixture of methanol / water. Titration against 0.1N sodium hydroxide was carried out using a Mettler DL-67 potentiometric titrator. Each milliliter of 0.1N sodium hydroxide VS is equivalent to 22.22 mg of Sildenafil citrate, calculated as C HNOS • CHO [3] .

Read full chapter

P. Verhamme, in Side Effects of Drugs Annual , 2011

Sildenafil has been associated with [ 29 ].

A 53-year-old woman with multiple pathology was admitted to the intensive care unit in respiratory distress. Sildenafil was added empirically to her extensive drug regimen, because of pulmonary hypertension. Her platelet count fell after 1 week. Heparin was first suspected and withdrawn, without effect. Sildenafil was then withdrawn and the platelet count started to rise. Two rechallenges with sildenafil because of worsening respiratory function led each time to a new pronounced fall in platelet count. Complete withdrawal of sildenafil resulted in sustained recovery.

The mechanism of this effect in this patient is not known.

Thorsteinn Loftsson PhD, in Jinjer Nina I9oaixYGze
, 2015

Sildenafil ( 475 daltons [Da]) is used to treat erectile dysfunction. As a free base, sildenafil is a sparingly soluble (0.01 mg/ml water), lipophilic (log =2.5) drug that permeates the biologic membranes rather easily (H-bond acceptors: 10; H-bond donors: 1). The aqueous solubility of sildenafil citrate is much greater than that of the free base or 4.1 mg/ml, and thus oral dosage forms usually contain sildenafil citrate. The following information was obtained from a pharmacokinetic study of sildenafil citrate, its oral bioavailability, food effects, and dose proportionality in 12–34 healthy male volunteers, and the data shown are the mean values [6] .

The following profiles were obtained after administration of a single oral dose of sildenafil (25–200 mg) as its citrate salt. Does the drug follow linear pharmacokinetics?

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